The selective photodeprotection of the NVoc-modified FGG tripeptide yields the transformation of its 1:1 receptor–ligand complex with cucurbit[8]uril into a homoternary FGG2@CB8 assembly. The resulting light-induced dimerization of the model peptide provides a tool for the implementation of stimuli-responsive supramolecular chemistry in biologically relevant contexts.
https://doi.org/10.1021/acs.joc.1c00464